2qfi: Difference between revisions

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[[Image:2qfi.gif|left|200px]]
{{Seed}}
[[Image:2qfi.png|left|200px]]


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{{STRUCTURE_2qfi|  PDB=2qfi  |  SCENE=  }}  
{{STRUCTURE_2qfi|  PDB=2qfi  |  SCENE=  }}  


'''Structure of the zinc transporter YiiP'''
===Structure of the zinc transporter YiiP===




==Overview==
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YiiP is a membrane transporter that catalyzes Zn2+/H+ exchange across the inner membrane of Escherichia coli. Mammalian homologs of YiiP play critical roles in zinc homeostasis and cell signaling. Here, we report the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution. YiiP is a homodimer held together in a parallel orientation through four Zn2+ ions at the interface of the cytoplasmic domains, whereas the two transmembrane domains swing out to yield a Y-shaped structure. In each protomer, the cytoplasmic domain adopts a metallochaperone-like protein fold; the transmembrane domain features a bundle of six transmembrane helices and a tetrahedral Zn2+ binding site located in a cavity that is open to both the membrane outer leaflet and the periplasm.
The line below this paragraph, {{ABSTRACT_PUBMED_17717154}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17717154}}


==About this Structure==
==About this Structure==
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[[Category: Transport protein]]
[[Category: Transport protein]]
[[Category: Zinc transporter]]
[[Category: Zinc transporter]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:52:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:57:34 2008''

Revision as of 07:57, 29 July 2008

File:2qfi.png

Template:STRUCTURE 2qfi

Structure of the zinc transporter YiiP

Template:ABSTRACT PUBMED 17717154

About this Structure

2QFI is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the zinc transporter YiiP., Lu M, Fu D, Science. 2007 Sep 21;317(5845):1746-8. Epub 2007 Aug 23. PMID:17717154

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