2qhm: Difference between revisions

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-[[Image:2qhm.jpg|left|200px]]
+{{Seed}}
+[[Image:2qhm.png|left|200px]]
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 {{STRUCTURE_2qhm|  PDB=2qhm  |  SCENE=  }}
-'''crystal structure of Chek1 in complex with inhibitor 2a'''
+===crystal structure of Chek1 in complex with inhibitor 2a===
-==Overview==
+<!--
-The development of 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones as inhibitors of Chk1 kinase is described. Introduction of a fused ring at the C7/C8 positions of the pyrazoloquinolinone provided an increase in potency while guidance from overlapping inhibitor bound Chk1 X-ray crystal structures contributed to the discovery of a potent and solubilizing propyl amine moiety in compound 52 (Chk1 IC(50)=3.1 nM).
+The line below this paragraph, {{ABSTRACT_PUBMED_17804227}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17804227 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17804227}}
 ==About this Structure==
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 [[Category: Kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 14:58:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:42:10 2008''

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