2qiq: Difference between revisions

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[[Image:2qiq.jpg|left|200px]]
{{Seed}}
[[Image:2qiq.png|left|200px]]


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{{STRUCTURE_2qiq|  PDB=2qiq  |  SCENE=  }}  
{{STRUCTURE_2qiq|  PDB=2qiq  |  SCENE=  }}  


'''Structure-based Design and Synthesis and Biological Evaluation of Peptidomimetic SARS-3CLpro Inhibitors'''
===Structure-based Design and Synthesis and Biological Evaluation of Peptidomimetic SARS-3CLpro Inhibitors===




==Overview==
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Structure-based design, synthesis, and biological evaluation of a series of peptidomimetic severe acute respiratory syndrome-coronavirus chymotrypsin-like protease inhibitors are described. These inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor 1 bound to SARS-CoV 3CLpro. Incorporation of Boc-Ser as the P(4)-ligand resulted in enhanced SARS-CoV 3CLpro inhibitory activity. Structural analysis of the inhibitor-bound X-ray structure revealed high binding affinity toward the enzyme.
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{{ABSTRACT_PUBMED_17855091}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Viral protein]]
[[Category: Viral protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:01:46 2008''
 
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