2qmd: Difference between revisions

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[[Image:2qmd.jpg|left|200px]]
{{Seed}}
[[Image:2qmd.png|left|200px]]


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{{STRUCTURE_2qmd|  PDB=2qmd  |  SCENE=  }}  
{{STRUCTURE_2qmd|  PDB=2qmd  |  SCENE=  }}  


'''Structure of BACE Bound to SCH722924'''
===Structure of BACE Bound to SCH722924===




==Overview==
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Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.
The line below this paragraph, {{ABSTRACT_PUBMED_18023580}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18023580}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:12:05 2008''
 
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