2qoz: Difference between revisions

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[[Image:2qoz.~~gif~~|left|200px]]

[[Image:2qoz.png|left|200px]]

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~~'''~~Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin. This file contains the 50S subunit of the first 70S ribosome, with neomycin bound. The entire crystal structure contains two 70S ribosomes.~~'''~~

===Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin. This file contains the 50S subunit of the first 70S ribosome, with neomycin bound. The entire crystal structure contains two 70S ribosomes.===

~~==Overview==~~

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The ~~widely used antibiotic spectinomycin inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome. Here~~, ~~we show that in crystals of~~ the ~~Escherichia coli 70S ribosome spectinomycin binding traps a distinct swiveling state of~~ the ~~head domain of the small ribosomal subunit~~. ~~Spectinomycin also alters the rate and completeness of reverse translocation in vitro~~. ~~These structural and biochemical data indicate that in solution spectinomycin sterically blocks swiveling of the head domain of the small ribosomal subunit and thereby disrupts~~ the ~~translocation cycle~~.

The line below this paragraph, {{ABSTRACT_PUBMED_17696316}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17696316 is the PubMed ID number.

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==About this Structure==

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[[Category: Ribosome]]

[[Category: Rna-protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:21:01 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:29:59 2008''

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-[[Image:2qoz.gif|left|200px]]
+{{Seed}}
+[[Image:2qoz.png|left|200px]]
 <!--
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 {{STRUCTURE_2qoz|  PDB=2qoz  |  SCENE=  }}
-'''Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin. This file contains the 50S subunit of the first 70S ribosome, with neomycin bound. The entire crystal structure contains two 70S ribosomes.'''
+===Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin. This file contains the 50S subunit of the first 70S ribosome, with neomycin bound. The entire crystal structure contains two 70S ribosomes.===
-==Overview==
+<!--
-The widely used antibiotic spectinomycin inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome. Here, we show that in crystals of the Escherichia coli 70S ribosome spectinomycin binding traps a distinct swiveling state of the head domain of the small ribosomal subunit. Spectinomycin also alters the rate and completeness of reverse translocation in vitro. These structural and biochemical data indicate that in solution spectinomycin sterically blocks swiveling of the head domain of the small ribosomal subunit and thereby disrupts the translocation cycle.
+The line below this paragraph, {{ABSTRACT_PUBMED_17696316}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17696316 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17696316}}
 ==About this Structure==
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 [[Category: Ribosome]]
 [[Category: Rna-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:21:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:29:59 2008''