2qr8: Difference between revisions

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[[Image:2qr8.jpg|left|200px]]
{{Seed}}
[[Image:2qr8.png|left|200px]]


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{{STRUCTURE_2qr8|  PDB=2qr8  |  SCENE=  }}  
{{STRUCTURE_2qr8|  PDB=2qr8  |  SCENE=  }}  


'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)'''
===2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)===




==Overview==
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The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
The line below this paragraph, {{ABSTRACT_PUBMED_18084304}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18084304 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084304}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:28:01 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:53:52 2008''
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