2vis: Difference between revisions
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New page: left|200px<br /> <applet load="2vis" size="450" color="white" frame="true" align="right" spinBox="true" caption="2vis, resolution 3.25Å" /> '''INFLUENZA VIRUS HEM... |
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[[Image:2vis.gif|left|200px]]<br /> | [[Image:2vis.gif|left|200px]]<br /><applet load="2vis" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2vis" size=" | |||
caption="2vis, resolution 3.25Å" /> | caption="2vis, resolution 3.25Å" /> | ||
'''INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY'''<br /> | '''INFLUENZA VIRUS HEMAGGLUTININ, (ESCAPE) MUTANT WITH THR 131 REPLACED BY ILE, COMPLEXED WITH A NEUTRALIZING ANTIBODY'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of the hemagglutinin (HA) of a mutant influenza virus that | The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies. | ||
==About this Structure== | ==About this Structure== | ||
2VIS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with NAG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2VIS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Gigant, B.]] | [[Category: Gigant, B.]] | ||
[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
[[Category: Skehel, J | [[Category: Skehel, J J.]] | ||
[[Category: Wharton, S | [[Category: Wharton, S A.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:56:14 2008'' | ||
