Acetylcholinesterase: Difference between revisions
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The active site region of this enzyme has two sites, a catalytic site and a peripheral site, which helps prebind the substrate and direct it toward the active site. When the 3-D structure was first determined, the big surprise was | The active site region of this enzyme has two sites, a catalytic site and a peripheral site, which helps prebind the substrate and direct it toward the active site. When the 3-D structure was first determined, the big surprise was | ||
that the active site was deep inside the protein, at the end or base of a | that the active site was deep inside the protein, at the end or base of a | ||
<scene name='Acetylcholinesterase/ | <scene name='Acetylcholinesterase/AChE_gorge/1'>long tunnel or gorge </scene>, | ||
lined with aromatic residues, with the peripheral site at the top or lip of this gorge. Amazingly, there were no acidic or negatively charged | lined with aromatic residues, with the peripheral site at the top or lip of this gorge. Amazingly, there were no acidic or negatively charged | ||
residues anywhere in these 2 sites or along this gorge, as would be expected to | residues anywhere in these 2 sites or along this gorge, as would be expected to | ||
