2r7g: Difference between revisions

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[[Image:2r7g.~~gif~~|left|200px]]

[[Image:2r7g.png|left|200px]]

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~~'''~~Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain~~'''~~

===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===

~~==Overview==~~

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The ~~adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation~~, ~~in part~~, ~~by displacing E2F transcription factors from~~ the ~~retinoblastoma protein~~ (~~pRb~~) ~~tumor suppressor. In this study we determined~~ the ~~crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A~~. ~~The structure and accompanying biochemical studies reveal that E1A~~-~~CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A~~-~~CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17974914}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17974914 is the PubMed ID number.

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==Disease==

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[[Category: Retinoblastoma protein]]

[[Category: Transcription repressor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 16~~:23:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:19:44 2008''

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-[[Image:2r7g.gif|left|200px]]
+{{Seed}}
+[[Image:2r7g.png|left|200px]]
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 {{STRUCTURE_2r7g|  PDB=2r7g  |  SCENE=  }}
-'''Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain'''
+===Structure of the retinoblastoma protein pocket domain in complex with adenovirus E1A CR1 domain===
-==Overview==
+<!--
-The adenovirus (Ad) E1A (Ad-E1A) oncoprotein mediates cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protein (pRb) tumor suppressor. In this study we determined the crystal structure of the pRb pocket domain in complex with conserved region 1 (CR1) of Ad5-E1A. The structure and accompanying biochemical studies reveal that E1A-CR1 binds at the interface of the A and B cyclin folds of the pRb pocket domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar residues to engage overlapping sites on pRb, implicating a novel molecular mechanism for pRb inactivation by a viral oncoprotein.
+The line below this paragraph, {{ABSTRACT_PUBMED_17974914}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17974914 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17974914}}
 ==Disease==
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 [[Category: Retinoblastoma protein]]
 [[Category: Transcription repressor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:23:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:19:44 2008''