2r7z: Difference between revisions

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[[Image:2r7z.gif|left|200px]]
{{Seed}}
[[Image:2r7z.png|left|200px]]


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{{STRUCTURE_2r7z|  PDB=2r7z  |  SCENE=  }}  
{{STRUCTURE_2r7z|  PDB=2r7z  |  SCENE=  }}  


'''Cisplatin lesion containing RNA polymerase II elongation complex'''
===Cisplatin lesion containing RNA polymerase II elongation complex===




==Overview==
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The anticancer drug cisplatin forms 1,2-d(GpG) DNA intrastrand cross-links (cisplatin lesions) that stall RNA polymerase II (Pol II) and trigger transcription-coupled DNA repair. Here we present a structure-function analysis of Pol II stalling at a cisplatin lesion in the DNA template. Pol II stalling results from a translocation barrier that prevents delivery of the lesion to the active site. AMP misincorporation occurs at the barrier and also at an abasic site, suggesting that it arises from nontemplated synthesis according to an 'A-rule' known for DNA polymerases. Pol II can bypass a cisplatin lesion that is artificially placed beyond the translocation barrier, even in the presence of a G.A mismatch. Thus, the barrier prevents transcriptional mutagenesis. The stalling mechanism differs from that of Pol II stalling at a photolesion, which involves delivery of the lesion to the active site and lesion-templated misincorporation that blocks transcription.
The line below this paragraph, {{ABSTRACT_PUBMED_17994106}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17994106 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17994106}}


==About this Structure==
==About this Structure==
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[[Category: Transferase/dna/rna complex]]
[[Category: Transferase/dna/rna complex]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:24:13 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:05:40 2008''

Revision as of 07:05, 23 July 2008

File:2r7z.png

Template:STRUCTURE 2r7z

Cisplatin lesion containing RNA polymerase II elongation complex

Template:ABSTRACT PUBMED 17994106

About this Structure

2R7Z is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Mechanism of transcriptional stalling at cisplatin-damaged DNA., Damsma GE, Alt A, Brueckner F, Carell T, Cramer P, Nat Struct Mol Biol. 2007 Dec;14(12):1127-33. Epub 2007 Nov 11. PMID:17994106

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