2r9a: Difference between revisions

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[[Image:2r9a.jpg|left|200px]]
{{Seed}}
[[Image:2r9a.png|left|200px]]


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{{STRUCTURE_2r9a|  PDB=2r9a  |  SCENE=  }}  
{{STRUCTURE_2r9a|  PDB=2r9a  |  SCENE=  }}  


'''Crystal structure of human XLF'''
===Crystal structure of human XLF===




==Overview==
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DNA double-strand breaks represent one of the most severe forms of DNA damage in mammalian cells. One pathway for repairing these breaks occurs via nonhomologous end-joining (NHEJ) and depends on XRCC4, LigaseIV, and Cernunnos, also called XLF. Although XLF stimulates XRCC4/LigaseIV to ligate mismatched and noncohesive DNA ends, the mechanistic basis for this function remains unclear. Here we report the structure of a partially functional 224 residue N-terminal fragment of human XLF. Despite only weak sequence similarity, XLF(1-170) shares structural homology with XRCC4(1-159). However, unlike the highly extended 130 A helical domain observed in XRCC4, XLF adopts a more compact, folded helical C-terminal region involving two turns and a twist, wrapping back to the structurally conserved N terminus. Mutational analysis of XLF and XRCC4 reveals a potential interaction interface, suggesting a mechanism for how XLF stimulates the ligation of mismatched ends.
The line below this paragraph, {{ABSTRACT_PUBMED_18158905}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18158905 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18158905}}


==About this Structure==
==About this Structure==
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[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Xlf]]
[[Category: Xlf]]
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Revision as of 23:51, 28 July 2008

File:2r9a.png

Template:STRUCTURE 2r9a

Crystal structure of human XLF

Template:ABSTRACT PUBMED 18158905

About this Structure

2R9A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining., Andres SN, Modesti M, Tsai CJ, Chu G, Junop MS, Mol Cell. 2007 Dec 28;28(6):1093-101. PMID:18158905

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