2ra4: Difference between revisions

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[[Image:2ra4.~~jpg~~|left|200px]]

[[Image:2ra4.png|left|200px]]

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~~'''~~Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)~~'''~~

===Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)===

~~==Overview==~~

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~~Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration~~, ~~including tissue remodeling, atherosclerosis and cancer metastasis. Here~~, the ~~crystal structure of human monocyte chemoattractant protein 4~~ (~~MCP-4) refined~~ at 1.~~70 A resolution is reported with crystallographic values R = 0~~.~~180 and R(free~~) ~~= 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix~~, ~~while the N-terminal part of the molecule forms an extended loop that~~ is ~~anchored to~~ the ~~rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51~~. ~~The crystal packing suggests the existence of MCP~~-~~4 dimers with a dimerization interface similar to those previously reported for the X~~-~~ray structures of MCP-1 and MCP-2.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18323622}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18323622 is the PubMed ID number.

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==About this Structure==

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[[Category: Pyrrolidone carboxylic acid]]

[[Category: Secreted]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 16~~:31:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:20 2008''

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-[[Image:2ra4.jpg|left|200px]]
+{{Seed}}
+[[Image:2ra4.png|left|200px]]
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 {{STRUCTURE_2ra4|  PDB=2ra4  |  SCENE=  }}
-'''Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)'''
+===Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)===
-==Overview==
+<!--
-Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration, including tissue remodeling, atherosclerosis and cancer metastasis. Here, the crystal structure of human monocyte chemoattractant protein 4 (MCP-4) refined at 1.70 A resolution is reported with crystallographic values R = 0.180 and R(free) = 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix, while the N-terminal part of the molecule forms an extended loop that is anchored to the rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51. The crystal packing suggests the existence of MCP-4 dimers with a dimerization interface similar to those previously reported for the X-ray structures of MCP-1 and MCP-2.
+The line below this paragraph, {{ABSTRACT_PUBMED_18323622}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18323622 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18323622}}
 ==About this Structure==
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 [[Category: Pyrrolidone carboxylic acid]]
 [[Category: Secreted]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:31:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:26:20 2008''