2rjc: Difference between revisions

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[[Image:2rjc.gif|left|200px]]
{{Seed}}
[[Image:2rjc.png|left|200px]]


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{{STRUCTURE_2rjc|  PDB=2rjc  |  SCENE=  }}  
{{STRUCTURE_2rjc|  PDB=2rjc  |  SCENE=  }}  


'''Crystal structure of L3MBTL1 protein in complex with MES'''
===Crystal structure of L3MBTL1 protein in complex with MES===




==Overview==
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Crystal structures of the L3MBTL1 MBT repeats in complex with histone H4 peptides dimethylated on Lys20 (H4K20me2) show that only the second of the three MBT repeats can bind mono- and dimethylated histone peptides. Its binding pocket has similarities to that of 53BP1 and is able to recognize the degree of histone lysine methylation. An unexpected mode of peptide-mediated dimerization suggests a possible mechanism for chromatin compaction by L3MBTL1.
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{{ABSTRACT_PUBMED_18026117}}


==About this Structure==
==About this Structure==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:01:20 2008''
 
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