2rmi: Difference between revisions

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[[Image:2rmi.gif|left|200px]]
{{Seed}}
[[Image:2rmi.png|left|200px]]


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{{STRUCTURE_2rmi|  PDB=2rmi  |  SCENE=  }}  
{{STRUCTURE_2rmi|  PDB=2rmi  |  SCENE=  }}  


'''3D NMR structure of astressin'''
===3D NMR structure of astressin===




==Overview==
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The C-terminally amidated CRF antagonist astressin binds to CRF-R1 or CRF-R2 receptors with low nanomolar affinity while the corresponding astressin-acid has &gt;100 times less affinity. To understand the role of the amide group in binding, the conformations of astressin-amide and astressin-acid were studied in DMSO using NMR techniques. The 3D NMR structures show that the backbones of both analogs prefer an alpha-helical conformation, with a small kink around Gln(26). However, astressin-amide has a well-defined helical structure from Leu(27) to Ile(41) and a conformation very similar to the bioactive conformation reported by our group (Grace et al., Proc Natl Acad Sci USA 2007, 104, 4858-4863). In contrast, astressin-acid has an irregular helical conformation from Arg(35) onward, including a rearrangement of the side chains in that region. This structural difference highlights the crucial role of the C-terminal amidation for stabilization of astressin's bioactive conformation.
The line below this paragraph, {{ABSTRACT_PUBMED_17657708}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17657708 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17657708}}


==About this Structure==
==About this Structure==
2RMI is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMI OCA].  
2RMI is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMI OCA].  


==Reference==
==Reference==
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[[Category: Urocortin]]
[[Category: Urocortin]]
[[Category: Urotensin]]
[[Category: Urotensin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:10:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:53:35 2008''

Revision as of 01:53, 28 July 2008

File:2rmi.png

Template:STRUCTURE 2rmi

3D NMR structure of astressin

Template:ABSTRACT PUBMED 17657708

About this Structure

2RMI is a Single protein structure. Full experimental information is available from OCA.

Reference

Astressin-amide and astressin-acid are structurally different in dimethylsulfoxide., Grace CR, Cervini L, Gulyas J, Rivier J, Riek R, Biopolymers. 2007 Oct 5-15;87(2-3):196-205. PMID:17657708

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