2rmj: Difference between revisions

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[[Image:2rmj.~~jpg~~|left|200px]]

[[Image:2rmj.png|left|200px]]

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~~'''~~Solution structure of RIG-I C-terminal domain~~'''~~

===Solution structure of RIG-I C-terminal domain===

~~==Overview==~~

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~~A DExD/H protein~~, ~~RIG-I~~, ~~is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns~~: ~~double-stranded (ds) and 5'ppp single-stranded (ss) RNA~~. ~~The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion~~. ~~Further analyses demonstrated that the C-terminal domain of RIG-I (CTD~~) ~~recognizes these RNA patterns and CTD coincides with~~ the ~~autorepression domain~~. ~~Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG~~-~~I ligands. Our results suggest that the bipartite structure of CTD regulates RIG~~-~~I on encountering viral RNA patterns.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18242112}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18242112 is the PubMed ID number.

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==About this Structure==

2RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].

2RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].

==Reference==

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[[Category: Rna-binding]]

[[Category: Ubl conjugation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 17~~:10:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:11:27 2008''

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-[[Image:2rmj.jpg|left|200px]]
+{{Seed}}
+[[Image:2rmj.png|left|200px]]
 <!--
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 {{STRUCTURE_2rmj|  PDB=2rmj  |  SCENE=  }}
-'''Solution structure of RIG-I C-terminal domain'''
+===Solution structure of RIG-I C-terminal domain===
-==Overview==
+<!--
-A DExD/H protein, RIG-I, is critical in innate antiviral responses by sensing viral RNA. Here we show that RIG-I recognizes two distinct viral RNA patterns: double-stranded (ds) and 5'ppp single-stranded (ss) RNA. The binding of RIG-I with dsRNA or 5'ppp ssRNA in the presence of ATP produces a common structure, as suggested by protease digestion. Further analyses demonstrated that the C-terminal domain of RIG-I (CTD) recognizes these RNA patterns and CTD coincides with the autorepression domain. Structural analysis of CTD by NMR spectroscopy in conjunction with mutagenesis revealed that the basic surface of CTD with a characteristic cleft interacts with RIG-I ligands. Our results suggest that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns.
+The line below this paragraph, {{ABSTRACT_PUBMED_18242112}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18242112 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18242112}}
 ==About this Structure==
-RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].
+RMJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMJ OCA].
 ==Reference==
@@ Line 44: / Line 48: @@
 [[Category: Rna-binding]]
 [[Category: Ubl conjugation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:10:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:11:27 2008''