2sob: Difference between revisions

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[[Image:2sob.gif|left|200px]]
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[[Image:2sob.png|left|200px]]


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{{STRUCTURE_2sob|  PDB=2sob  |  SCENE=  }}  
{{STRUCTURE_2sob|  PDB=2sob  |  SCENE=  }}  


'''SN-OB, OB-FOLD SUB-DOMAIN OF STAPHYLOCOCCAL NUCLEASE, NMR, 10 STRUCTURES'''
===SN-OB, OB-FOLD SUB-DOMAIN OF STAPHYLOCOCCAL NUCLEASE, NMR, 10 STRUCTURES===




==Overview==
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Similar folds often occur in proteins with dissimilar sequences. The OB-fold forms a part of the structures of at least seven non-homologous proteins that share either oligonucleotide or oligosaccharide binding functions. A 1-103 fragment corresponding to the OB-fold of the 149 amino acid residue staphylococcal nuclease gives NMR spectra characteristic of an unfolded protein, i.e. the wild-type nuclease sequence is insufficient to maintain a stable tertiary structure in the absence of the C-terminal one-third of this single-domain protein. By contrast, the 1-103 fragment of nuclease with the mutations Val66Leu and Gly88Val adopts a stable tertiary structure. The NMR solution structure of this latter fragment is a close variation of the OB-fold found in the X-ray structure of the parent protein. The Val66Leu and Gly88Val mutations appear to stabilize tertiary structure by consolidating the hydrophobic core of the nuclease OB-fold sub-domain. Taken together, these results suggest that recurrent structural motifs such as the OB-fold may in some cases represent vestiges of autonomous folding units that, during evolution, have become integrated into more complex cooperative folding domains.
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{{ABSTRACT_PUBMED_7608966}}


==About this Structure==
==About this Structure==
2SOB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sob 1sob]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SOB OCA].  
2SOB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1sob 1sob]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SOB OCA].  


==Reference==
==Reference==
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[[Category: Gittis, A G.]]
[[Category: Gittis, A G.]]
[[Category: Shortle, D.]]
[[Category: Shortle, D.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:20:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:58:40 2008''

Revision as of 13:58, 27 July 2008

File:2sob.png

Template:STRUCTURE 2sob

SN-OB, OB-FOLD SUB-DOMAIN OF STAPHYLOCOCCAL NUCLEASE, NMR, 10 STRUCTURES

Template:ABSTRACT PUBMED 7608966

About this Structure

2SOB is a Single protein structure of sequence from Staphylococcus aureus. This structure supersedes the now removed PDB entry 1sob. Full experimental information is available from OCA.

Reference

NMR structure of a stable "OB-fold" sub-domain isolated from staphylococcal nuclease., Alexandrescu AT, Gittis AG, Abeygunawardana C, Shortle D, J Mol Biol. 1995 Jul 7;250(2):134-43. PMID:7608966

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