2srt: Difference between revisions

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[[Image:2srt.gif|left|200px]]
{{Seed}}
[[Image:2srt.png|left|200px]]


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{{STRUCTURE_2srt|  PDB=2srt  |  SCENE=  }}  
{{STRUCTURE_2srt|  PDB=2srt  |  SCENE=  }}  


'''CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR'''
===CATALYTIC DOMAIN OF HUMAN STROMELYSIN-1 AT PH 5.5 AND 40OC COMPLEXED WITH INHIBITOR===




==Overview==
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The three-dimensional structure of the catalytic domain of stromelysin-1 complexed with an N-carboxyl alkyl inhibitor has been determined by NMR methods. The global fold consists of three helices, a five stranded beta-sheet and a methionine located in a turn near the catalytic histidines, classifying stromelysin-1 as a metzincin. Stromelysin-1 is unique in having two independent zinc binding sites: a catalytic site and a structural site. The inhibitor binds in an extended conformation. The S1' subsite is a deep hydrophobic pocket, whereas S2' appears shallow and S3' open.
The line below this paragraph, {{ABSTRACT_PUBMED_7656014}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7656014}}


==About this Structure==
==About this Structure==
2SRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1srt 1srt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA].  
2SRT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1srt 1srt]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2SRT OCA].  


==Reference==
==Reference==
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[[Category: Gooley, P R.]]
[[Category: Gooley, P R.]]
[[Category: Metzincin]]
[[Category: Metzincin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:21:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:29:17 2008''
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