2ush: Difference between revisions

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[[Image:2ush.jpg|left|200px]]
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[[Image:2ush.png|left|200px]]


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{{STRUCTURE_2ush|  PDB=2ush  |  SCENE=  }}  
{{STRUCTURE_2ush|  PDB=2ush  |  SCENE=  }}  


'''5'-NUCLEOTIDASE FROM E. COLI'''
===5'-NUCLEOTIDASE FROM E. COLI===




==Overview==
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The crystal structure of 5'-nucleotidase (5'-NT) from E. coli, also known as UDP-sugar hydrolase, has been determined at 1.7 A resolution. Two zinc ions are present in the active site, which is located in a cleft between two domains. The dimetal center and a catalytic Asp-His dyad are the main players in the catalytic mechanism. Structure-based sequence comparisons show that the structure also provides a model for animal 5'-NTs, which together with other ectonucleotidases terminate the action of nucleotides as extracellular signaling substances in the nervous system.
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{{ABSTRACT_PUBMED_10331872}}


==About this Structure==
==About this Structure==
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[[Category: Phosphatase]]
[[Category: Phosphatase]]
[[Category: Udp-sugar hydrolase]]
[[Category: Udp-sugar hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:28:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:19:57 2008''

Revision as of 12:19, 27 July 2008

File:2ush.png

Template:STRUCTURE 2ush

5'-NUCLEOTIDASE FROM E. COLI

Template:ABSTRACT PUBMED 10331872

About this Structure

2USH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site., Knofel T, Strater N, Nat Struct Biol. 1999 May;6(5):448-53. PMID:10331872

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