2uv3: Difference between revisions

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[[Image:2uv3.gif|left|200px]]
{{Seed}}
[[Image:2uv3.png|left|200px]]


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{{STRUCTURE_2uv3|  PDB=2uv3  |  SCENE=  }}  
{{STRUCTURE_2uv3|  PDB=2uv3  |  SCENE=  }}  


'''STRUCTURE OF THE SIGNAL-REGULATORY PROTEIN (SIRP) ALPHA DOMAIN THAT BINDS CD47.'''
===STRUCTURE OF THE SIGNAL-REGULATORY PROTEIN (SIRP) ALPHA DOMAIN THAT BINDS CD47.===




==Overview==
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Signal regulatory protein (SIRP) alpha is a membrane receptor that sends inhibitory signals to myeloid cells by engagement of CD47. The high resolution x-ray structure of the N-terminal ligand binding domain shows it to have a distinctive immunoglobulin superfamily V-like fold. Site-directed mutagenesis suggests that CD47 is bound at a surface involving the BC, FG, and DE loops, which distinguishes it from other immunoglobulin superfamily surface proteins that use the faces of the fold, but resembles antigen receptors. The SIRP interaction is confined to a single domain, and its use of an extended DE loop strengthens the similarity with T cell receptor binding and the suggestion that they are closely related in evolution. The employment of loops to form the CD47-binding surface provides a mechanism for small sequence changes to modulate binding specificity, explaining the different binding properties of SIRP family members.
The line below this paragraph, {{ABSTRACT_PUBMED_17369261}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17369261 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17369261}}


==About this Structure==
==About this Structure==
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[[Category: Signal-regulatory protein alpha]]
[[Category: Signal-regulatory protein alpha]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:33:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:31:18 2008''

Revision as of 14:31, 28 July 2008

File:2uv3.png

Template:STRUCTURE 2uv3

STRUCTURE OF THE SIGNAL-REGULATORY PROTEIN (SIRP) ALPHA DOMAIN THAT BINDS CD47.

Template:ABSTRACT PUBMED 17369261

About this Structure

2UV3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the macrophage signal regulatory protein alpha (SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that used by T cell receptors., Hatherley D, Harlos K, Dunlop DC, Stuart DI, Barclay AN, J Biol Chem. 2007 May 11;282(19):14567-75. Epub 2007 Mar 16. PMID:17369261

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