2uw0: Difference between revisions

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[[Image:2uw0.gif|left|200px]]
{{Seed}}
[[Image:2uw0.png|left|200px]]


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{{STRUCTURE_2uw0|  PDB=2uw0  |  SCENE=  }}  
{{STRUCTURE_2uw0|  PDB=2uw0  |  SCENE=  }}  


'''STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE'''
===STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE===




==Overview==
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6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition and effects on cellular signaling pathways characteristic of PKB inhibition.
The line below this paragraph, {{ABSTRACT_PUBMED_17451235}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17451235}}


==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transferase/inhibitor complex]]
[[Category: Transferase/inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:37:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:03:37 2008''

Revision as of 14:03, 27 July 2008

File:2uw0.png

Template:STRUCTURE 2uw0

STRUCTURE OF PKA-PKB CHIMERA COMPLEXED WITH 6-(4-(4-(4-CHLORO-PHENYL)-PIPERIDIN-4-YL)-PHENYL)-9H-PURINE

Template:ABSTRACT PUBMED 17451235

About this Structure

2UW0 is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design., Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I, J Med Chem. 2007 May 17;50(10):2289-92. Epub 2007 Apr 24. PMID:17451235

Page seeded by OCA on Sun Jul 27 17:03:37 2008

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