2uwq: Difference between revisions

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[[Image:2uwq.~~jpg~~|left|200px]]

[[Image:2uwq.png|left|200px]]

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~~'''~~SOLUTION STRUCTURE OF ASPP2 N-TERMINUS~~'''~~

===SOLUTION STRUCTURE OF ASPP2 N-TERMINUS===

~~==Overview==~~

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~~Proteins of~~ the ~~ASPP family bind~~ to ~~p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both~~ the ~~mechanism of enhancement~~/~~repression of apoptosis and the molecular basis for their different responses remain unknown~~. ~~To address the role of the N-termini of pro-apoptotic ASPP proteins~~, ~~we solved~~ the ~~solution structure of N-ASPP2 (1-83) by NMR spectroscopy~~. ~~The structure of this domain reveals a beta~~-~~Grasp ubiquitin~~-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.

The line below this paragraph, {{ABSTRACT_PUBMED_17594908}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17594908 is the PubMed ID number.

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==About this Structure==

2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].

2UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].

==Reference==

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[[Category: Sh3-domain]]

[[Category: Ubiquitin-like]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 17~~:41:06 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:22:07 2008''

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-[[Image:2uwq.jpg|left|200px]]
+{{Seed}}
+[[Image:2uwq.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2uwq|  PDB=2uwq  |  SCENE=  }}
-'''SOLUTION STRUCTURE OF ASPP2 N-TERMINUS'''
+===SOLUTION STRUCTURE OF ASPP2 N-TERMINUS===
-==Overview==
+<!--
-Proteins of the ASPP family bind to p53 and regulate p53-mediated apoptosis. Two family members, ASPP1 and ASPP2, have pro-apoptotic functions while iASPP shows anti-apoptotic responses. However, both the mechanism of enhancement/repression of apoptosis and the molecular basis for their different responses remain unknown. To address the role of the N-termini of pro-apoptotic ASPP proteins, we solved the solution structure of N-ASPP2 (1-83) by NMR spectroscopy. The structure of this domain reveals a beta-Grasp ubiquitin-like fold. Our findings suggest a possible role for the N-termini of ASPP proteins in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic function.
+The line below this paragraph, {{ABSTRACT_PUBMED_17594908}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17594908 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17594908}}
 ==About this Structure==
-UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
+UWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UWQ OCA].
 ==Reference==
@@ Line 33: / Line 37: @@
 [[Category: Sh3-domain]]
 [[Category: Ubiquitin-like]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:41:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:22:07 2008''