2uzg: Difference between revisions

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[[Image:2uzg.jpg|left|200px]]
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[[Image:2uzg.png|left|200px]]


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{{STRUCTURE_2uzg|  PDB=2uzg  |  SCENE=  }}  
{{STRUCTURE_2uzg|  PDB=2uzg  |  SCENE=  }}  


'''ZF-UBP DOMAIN OF VDU1'''
===ZF-UBP DOMAIN OF VDU1===




==Overview==
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USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
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{{ABSTRACT_PUBMED_17766394}}


==About this Structure==
==About this Structure==
2UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA].  
2UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA].  


==Reference==
==Reference==
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[[Category: Zinc]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:52:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:56:54 2008''

Revision as of 14:56, 27 July 2008

File:2uzg.png

Template:STRUCTURE 2uzg

ZF-UBP DOMAIN OF VDU1

Template:ABSTRACT PUBMED 17766394

About this Structure

2UZG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394

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