1a58: Difference between revisions

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[[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1a58, resolution 1.95Å" />

'''CYCLOPHILIN FROM BRUGIA MALAYI'''<br />

==Overview==

A structure of residues 1-177 of the cyclophilin domain of a large, divergent cyclophilin from the filarial nematode parasite Brugia malayi, has been crystallised and solved in two different crystal forms. The, active site has a similar structure to that of human cyclophilin A. Two of, the 13 residues important in forming the human cyclophilin A/cyclosporin A, complex are altered in the B. malayi cyclophilin and explain the, relatively poor inhibition of peptidyl prolyl isomerase activity by, cyclosporin A.

A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.

==About this Structure==

1A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].

1A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].

==Reference==

Line 15:

[[Category: Husi, H.]]

[[Category: Kontopidis, G.]]

[[Category: Page, A.P.]]

[[Category: Page, A P.]]

[[Category: Taylor, P.]]

[[Category: Walkinshaw, M.D.]]

[[Category: Walkinshaw, M D.]]

[[Category: isomerase]]

[[Category: ppiase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 10~~:37:~~01 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:40:59 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1a58.gif|left|200px]]<br /><applet load="1a58" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1a58, resolution 1.95&Aring;" />
 '''CYCLOPHILIN FROM BRUGIA MALAYI'''<br />
 ==Overview==
-A structure of residues 1-177 of the cyclophilin domain of a large, divergent cyclophilin from the filarial nematode parasite Brugia malayi, has been crystallised and solved in two different crystal forms. The, active site has a similar structure to that of human cyclophilin A. Two of, the 13 residues important in forming the human cyclophilin A/cyclosporin A, complex are altered in the B. malayi cyclophilin and explain the, relatively poor inhibition of peptidyl prolyl isomerase activity by, cyclosporin A.
+A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
 ==About this Structure==
-A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].
+A58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Husi, H.]]
 [[Category: Kontopidis, G.]]
-[[Category: Page, A.P.]]
+[[Category: Page, A P.]]
 [[Category: Taylor, P.]]
-[[Category: Walkinshaw, M.D.]]
+[[Category: Walkinshaw, M D.]]
 [[Category: isomerase]]
 [[Category: ppiase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:37:01 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:40:59 2008''