1a6f: Difference between revisions
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New page: left|200px<br /><applet load="1a6f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a6f, resolution 2.6Å" /> '''RNASE P PROTEIN FROM ... |
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[[Image:1a6f.gif|left|200px]]<br /><applet load="1a6f" size=" | [[Image:1a6f.gif|left|200px]]<br /><applet load="1a6f" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1a6f, resolution 2.6Å" /> | caption="1a6f, resolution 2.6Å" /> | ||
'''RNASE P PROTEIN FROM BACILLUS SUBTILIS'''<br /> | '''RNASE P PROTEIN FROM BACILLUS SUBTILIS'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of Bacillus subtilis ribonuclease P protein is | The crystal structure of Bacillus subtilis ribonuclease P protein is reported at 2.6 angstroms resolution. This protein binds to ribonuclease P RNA to form a ribonucleoprotein holoenzyme with optimal catalytic activity. Mutagenesis and biochemical data indicate that an unusual left-handed betaalphabeta crossover connection and a large central cleft in the protein form conserved RNA binding sites; a metal binding loop may comprise a third RNA binding site. The unusual topology is partly shared with ribosomal protein S5 and the ribosomal translocase elongation factor G, which suggests evolution from a common RNA binding ancestor in the primordial translational apparatus. | ||
==About this Structure== | ==About this Structure== | ||
1A6F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with ZN and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] Full crystallographic information is available from [http:// | 1A6F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6F OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Ribonuclease P]] | [[Category: Ribonuclease P]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Christianson, D | [[Category: Christianson, D W.]] | ||
[[Category: Stams, T.]] | [[Category: Stams, T.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: subunit]] | [[Category: subunit]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:35 2008'' | ||
