1a7h: Difference between revisions

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[[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1a7h, resolution 2.56Å" />

'''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''<br />

==Overview==

The 2-domain gammaS-crystallin, a highly conserved early evolutionary, off-shoot of the gamma-crystallin family, is located in the water-rich, region of eye lenses. The expressed C-terminal domain, gammaS-C, has been, crystallized and the 2.56 A X-ray structure determined. There are two, domains in the asymmetric unit which pair about a distorted twofold axis., One of the domains has an altered conformation in a highly conserved, region of the protein, the tyrosine corner. The distorted gammaS-C dimer, of domains is compared with the highly symmetrical, equivalent recombinant, dimer of C-terminal domains from gammaB-crystallin. Sequence changes close, to the interface, that distinguish gammaS from the other, gamma-crystallins, are examined in order to evaluate their role in, symmetrical domain pairing.

The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.

==About this Structure==

1A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA].

1A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA].

==Reference==

Line 13:

[[Category: Bos taurus]]

[[Category: Single protein]]

[[Category: Basak, A.K.]]

[[Category: Basak, A K.]]

[[Category: Slingsby, C.]]

[[Category: eye lens protein]]

Line 20:

[[Category: multigene family]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 10~~:39:~~56 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:42 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1a7h.gif|left|200px]]<br /><applet load="1a7h" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1a7h, resolution 2.56&Aring;" />
 '''GAMMA S CRYSTALLIN C-TERMINAL DOMAIN'''<br />
 ==Overview==
-The 2-domain gammaS-crystallin, a highly conserved early evolutionary, off-shoot of the gamma-crystallin family, is located in the water-rich, region of eye lenses. The expressed C-terminal domain, gammaS-C, has been, crystallized and the 2.56 A X-ray structure determined. There are two, domains in the asymmetric unit which pair about a distorted twofold axis., One of the domains has an altered conformation in a highly conserved, region of the protein, the tyrosine corner. The distorted gammaS-C dimer, of domains is compared with the highly symmetrical, equivalent recombinant, dimer of C-terminal domains from gammaB-crystallin. Sequence changes close, to the interface, that distinguish gammaS from the other, gamma-crystallins, are examined in order to evaluate their role in, symmetrical domain pairing.
+The 2-domain gammaS-crystallin, a highly conserved early evolutionary off-shoot of the gamma-crystallin family, is located in the water-rich region of eye lenses. The expressed C-terminal domain, gammaS-C, has been crystallized and the 2.56 A X-ray structure determined. There are two domains in the asymmetric unit which pair about a distorted twofold axis. One of the domains has an altered conformation in a highly conserved region of the protein, the tyrosine corner. The distorted gammaS-C dimer of domains is compared with the highly symmetrical, equivalent recombinant dimer of C-terminal domains from gammaB-crystallin. Sequence changes close to the interface, that distinguish gammaS from the other gamma-crystallins, are examined in order to evaluate their role in symmetrical domain pairing.
 ==About this Structure==
-A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA].
+A7H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7H OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Bos taurus]]
 [[Category: Single protein]]
-[[Category: Basak, A.K.]]
+[[Category: Basak, A K.]]
 [[Category: Slingsby, C.]]
 [[Category: eye lens protein]]
@@ Line 20: / Line 20: @@
 [[Category: multigene family]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:39:56 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:42 2008''