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| {{STRUCTURE_2vb6| PDB=2vb6 | SCENE= }} | | {{STRUCTURE_2vb6| PDB=2vb6 | SCENE= }} |
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| '''MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)'''
| | ===MYOSIN VI (MD-INSERT2-CAM, DELTA INSERT1) POST-RIGOR STATE (CRYSTAL FORM 2)=== |
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| ==Overview==
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| Myosin VI has an unexpectedly large swing of its lever arm (powerstroke) that optimizes its unique reverse direction movement. The basis for this is an unprecedented rearrangement of the subdomain to which the lever arm is attached, referred to as the converter. It is unclear at what point(s) in the myosin VI ATPase cycle rearrangements in the converter occur, and how this would effect lever arm position. We solved the structure of myosin VI with an ATP analogue (ADP.BeF3) bound in its nucleotide-binding pocket. The structure reveals that no rearrangement in the converter occur upon ATP binding. Based on previously solved myosin structures, our structure suggests that no reversal of the powerstroke occurs during detachment of myosin VI from actin. The structure also reveals novel features of the myosin VI motor that may be important in maintaining the converter conformation during detachment from actin, and other features that may promote rapid rearrangements in the structure following actin detachment that enable hydrolysis of ATP.
| | The line below this paragraph, {{ABSTRACT_PUBMED_18046460}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 18046460 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_18046460}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Myosin vi]] | | [[Category: Myosin vi]] |
| [[Category: Post-rigor state]] | | [[Category: Post-rigor state]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 18:32:09 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:58:43 2008'' |
