2vcg: Difference between revisions

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[[Image:2vcg.~~jpg~~|left|200px]]

[[Image:2vcg.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17~~'''~~

===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===

~~==Overview==~~

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~~We synthesized biarylalanine-containing hydroxamic acids and tested them~~ on ~~immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones~~). ~~We obtained an X~~-~~ray structure with a HDAC6~~-selective inhibitor with the bacterial deacetylase HDAH. Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds.

The line below this paragraph, {{ABSTRACT_PUBMED_18054239}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18054239 is the PubMed ID number.

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==About this Structure==

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[[Category: Hydrolase]]

[[Category: Inhibitor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 18:35:34 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:24 2008''

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-[[Image:2vcg.jpg|left|200px]]
+{{Seed}}
+[[Image:2vcg.png|left|200px]]
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 {{STRUCTURE_2vcg|  PDB=2vcg  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17'''
+===CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17===
-==Overview==
+<!--
-We synthesized biarylalanine-containing hydroxamic acids and tested them on immunoprecipitated HDAC1 and HDAC6 and show a subtype selectivity for HDAC6 that was confirmed in cells by Western blot (tubulin vs histones). We obtained an X-ray structure with a HDAC6-selective inhibitor with the bacterial deacetylase HDAH. Docking studies were carried out using HDAC1 and HDAC6 protein models. Antiproliferative activity was shown on cancer cells for selected compounds.
+The line below this paragraph, {{ABSTRACT_PUBMED_18054239}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18054239 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18054239}}
 ==About this Structure==
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 [[Category: Hydrolase]]
 [[Category: Inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:35:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:48:24 2008''