2vgp: Difference between revisions

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[[Image:2vgp.~~jpg~~|left|200px]]

[[Image:2vgp.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR~~'''~~

===CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR===

~~==Overview==~~

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~~Aurora family kinases regulate important events during mitosis including centrosome maturation and separation~~, ~~mitotic spindle assembly~~, ~~and chromosome segregation. Misregulation of Aurora kinases due~~ to ~~genetic amplification and protein overexpression results in aneuploidy and may contribute to tumorigenesis. Here we report~~ the ~~discovery of new small molecule aminothiazole inhibitors of Aurora kinases with exceptional kinase selectivity and report a 1~~.~~7 A cocrystal structure with the Aurora B:INCENP complex from Xenopus laevis~~. ~~The compounds recapitulate~~ the ~~hallmarks of Aurora kinase inhibition, including decreased histone H3 serine 10 phosphorylation, failure to complete cytokinesis, and endoreduplication~~.

The line below this paragraph, {{ABSTRACT_PUBMED_18307303}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18307303 is the PubMed ID number.

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==About this Structure==

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[[Category: Serine/threonine-protein kinase]]

[[Category: Transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun ~~May 4 18~~:46:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:36:18 2008''

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-[[Image:2vgp.jpg|left|200px]]
+{{Seed}}
+[[Image:2vgp.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2vgp|  PDB=2vgp  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR'''
+===CRYSTAL STRUCTURE OF AURORA B KINASE IN COMPLEX WITH A AMINOTHIAZOLE INHIBITOR===
-==Overview==
+<!--
-Aurora family kinases regulate important events during mitosis including centrosome maturation and separation, mitotic spindle assembly, and chromosome segregation. Misregulation of Aurora kinases due to genetic amplification and protein overexpression results in aneuploidy and may contribute to tumorigenesis. Here we report the discovery of new small molecule aminothiazole inhibitors of Aurora kinases with exceptional kinase selectivity and report a 1.7 A cocrystal structure with the Aurora B:INCENP complex from Xenopus laevis. The compounds recapitulate the hallmarks of Aurora kinase inhibition, including decreased histone H3 serine 10 phosphorylation, failure to complete cytokinesis, and endoreduplication.
+The line below this paragraph, {{ABSTRACT_PUBMED_18307303}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18307303 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18307303}}
 ==About this Structure==
@@ Line 52: / Line 56: @@
 [[Category: Serine/threonine-protein kinase]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:46:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:36:18 2008''