2vie: Difference between revisions

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[[Image:2vie.~~jpg~~|left|200px]]

[[Image:2vie.png|left|200px]]

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~~'''~~HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY-3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE~~'''~~

===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY-3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE===

~~==Overview==~~

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~~This paper describes the discovery of non-peptidic~~, ~~potent~~, ~~and selective hydroxy ethylamine~~ (~~HEA) inhibitors of BACE-1 by replacement of the prime side of a lead di-amide 2~~. ~~Inhibitors with nanosmolar potency and high selectivity were identified~~. ~~Depending on the nature of the P(1)('~~) ~~and P(2)(') substituents~~, ~~two different binding modes were observed in X~~-~~ray co~~-~~crystal structures.~~

The line below this paragraph, {{ABSTRACT_PUBMED_18166458}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 18166458 is the PubMed ID number.

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==About this Structure==

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[[Category: Transmembrane]]

[[Category: Zymogen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:51:45 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:24:14 2008''

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-[[Image:2vie.jpg|left|200px]]
+{{Seed}}
+[[Image:2vie.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2vie|  PDB=2vie  |  SCENE=  }}
-'''HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY-3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE'''
+===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-1-BENZYL-2-HYDROXY-3-((1,1,5-TRIMETHYLHEXYL)AMINO)PROPYL)-3-(ETHYLAMINO)-5-(2-OXOPYRROLIDIN-1-YL)BENZAMIDE===
-==Overview==
+<!--
-This paper describes the discovery of non-peptidic, potent, and selective hydroxy ethylamine (HEA) inhibitors of BACE-1 by replacement of the prime side of a lead di-amide 2. Inhibitors with nanosmolar potency and high selectivity were identified. Depending on the nature of the P(1)(') and P(2)(') substituents, two different binding modes were observed in X-ray co-crystal structures.
+The line below this paragraph, {{ABSTRACT_PUBMED_18166458}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 18166458 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_18166458}}
 ==About this Structure==
@@ Line 63: / Line 67: @@
 [[Category: Transmembrane]]
 [[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:51:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:24:14 2008''