1aar: Difference between revisions

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[[Image:1aar.jpg|left|200px]]<br /><applet load="1aar" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1aar.jpg|left|200px]]<br /><applet load="1aar" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1aar, resolution 2.3Å" />

'''STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)'''<br />

==Overview==

Covalent ligation of multiubiquitin chains targets eukaryotic proteins for, degradation. In such multiubiquitin chains, successive ubiquitins are, linked by an isopeptide bond involving the side chain of Lys48 and the, carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate, has been determined and refined at 2.3-A resolution. The molecule has, internal approximate 2-fold symmetry with multiple hydrophobic and, hydrophilic contacts along the 2-fold axis. The structure of the, diubiquitin conjugate suggests determinants for recognition of, multiubiquitin chains. A model for the interaction of diubiquitin and a, ubiquitin conjugating enzyme (E2) is proposed.

Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. In such multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate has been determined and refined at 2.3-A resolution. The molecule has internal approximate 2-fold symmetry with multiple hydrophobic and hydrophilic contacts along the 2-fold axis. The structure of the diubiquitin conjugate suggests determinants for recognition of multiubiquitin chains. A model for the interaction of diubiquitin and a ubiquitin conjugating enzyme (E2) is proposed.

==About this Structure==

1AAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1AAR OCA].

1AAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AAR OCA].

==Reference==

Line 15:

[[Category: Carson, M.]]

[[Category: Chen, Z.]]

[[Category: Cook, W.J.]]

[[Category: Cook, W J.]]

[[Category: Jeffrey, L.C.]]

[[Category: Jeffrey, L C.]]

[[Category: Pickart, C.M.]]

[[Category: Pickart, C M.]]

[[Category: ubiquitin]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 10~~:43:~~19 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:39 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1aar.jpg|left|200px]]<br /><applet load="1aar" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1aar.jpg|left|200px]]<br /><applet load="1aar" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1aar, resolution 2.3&Aring;" />
 '''STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)'''<br />
 ==Overview==
-Covalent ligation of multiubiquitin chains targets eukaryotic proteins for, degradation. In such multiubiquitin chains, successive ubiquitins are, linked by an isopeptide bond involving the side chain of Lys48 and the, carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate, has been determined and refined at 2.3-A resolution. The molecule has, internal approximate 2-fold symmetry with multiple hydrophobic and, hydrophilic contacts along the 2-fold axis. The structure of the, diubiquitin conjugate suggests determinants for recognition of, multiubiquitin chains. A model for the interaction of diubiquitin and a, ubiquitin conjugating enzyme (E2) is proposed.
+Covalent ligation of multiubiquitin chains targets eukaryotic proteins for degradation. In such multiubiquitin chains, successive ubiquitins are linked by an isopeptide bond involving the side chain of Lys48 and the carboxyl group of Gly76. The crystal structure of a diubiquitin conjugate has been determined and refined at 2.3-A resolution. The molecule has internal approximate 2-fold symmetry with multiple hydrophobic and hydrophilic contacts along the 2-fold axis. The structure of the diubiquitin conjugate suggests determinants for recognition of multiubiquitin chains. A model for the interaction of diubiquitin and a ubiquitin conjugating enzyme (E2) is proposed.
 ==About this Structure==
-AAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AAR OCA].
+AAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AAR OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Carson, M.]]
 [[Category: Chen, Z.]]
-[[Category: Cook, W.J.]]
+[[Category: Cook, W J.]]
-[[Category: Jeffrey, L.C.]]
+[[Category: Jeffrey, L C.]]
-[[Category: Pickart, C.M.]]
+[[Category: Pickart, C M.]]
 [[Category: ubiquitin]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:43:19 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:39 2008''