2vj9: Difference between revisions

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[[Image:2vj9.jpg|left|200px]]
{{Seed}}
[[Image:2vj9.png|left|200px]]


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{{STRUCTURE_2vj9|  PDB=2vj9  |  SCENE=  }}  
{{STRUCTURE_2vj9|  PDB=2vj9  |  SCENE=  }}  


'''HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE'''
===HUMAN BACE-1 IN COMPLEX WITH N-((1S,2R)-3-(CYCLOHEXYLAMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-3-(ETHYLAMINO)-5-(2-OXO-1-PYRROLIDINYL)BENZAMIDE===




==Overview==
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This paper describes the discovery of non-peptidic, potent, and selective hydroxy ethylamine (HEA) inhibitors of BACE-1 by replacement of the prime side of a lead di-amide 2. Inhibitors with nanosmolar potency and high selectivity were identified. Depending on the nature of the P(1)(') and P(2)(') substituents, two different binding modes were observed in X-ray co-crystal structures.
The line below this paragraph, {{ABSTRACT_PUBMED_18166458}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18166458 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18166458}}


==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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