2vlz: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2vlz.jpg|left|200px]]
{{Seed}}
[[Image:2vlz.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2vlz|  PDB=2vlz  |  SCENE=  }}  
{{STRUCTURE_2vlz|  PDB=2vlz  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF PEROXYMYOGLOBIN GENERATED BY CRYORADIOLYTIC REDUCTION OF MYOGLOBIN COMPOUND III'''
===CRYSTAL STRUCTURE OF PEROXYMYOGLOBIN GENERATED BY CRYORADIOLYTIC REDUCTION OF MYOGLOBIN COMPOUND III===


==Overview==
The biological conversions of O(2) and peroxides to water as well as certain incorporations of oxygen atoms into small organic molecules can be catalyzed by metal ions in different clusters or cofactors. The catalytic cycle of these reactions passes through similar metal-based complexes in which one oxygen- or peroxide-derived oxygen atom is coordinated to an oxidized form of the catalytic metal center. In haem-based peroxidases or oxygenases the ferryl (Fe(IV)O) form is important in compound I and compound II, which are two and one oxidation equivalents higher than the ferric (Fe(III)) form, respectively. In this study we report the 1.35 A structure of a compound II model protein, obtained by reacting hydrogen peroxide with ferric myoglobin at pH 5.2. The molecular geometry is virtually unchanged compared to the ferric form, indicating that these reactive intermediates do not undergo large structural changes. It is further suggested that at low pH the dominating compound II resonance form is a hydroxyl radical ferric iron rather than an oxo-ferryl form, based on the short hydrogen bonding to the distal histidine (2.70 A) and the Fe...O distance. The 1.92 A Fe...O distance is in agreement with an EXAFS study of compound II in horseradish peroxidase.


==About this Structure==
==About this Structure==
2VLZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLZ OCA].  
2VLZ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VLZ OCA].  


==Reference==
==Reference==
An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2., Hersleth HP, Dalhus B, Gorbitz CH, Andersson KK, J Biol Inorg Chem. 2002 Mar;7(3):299-304. Epub 2001 Oct 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11935353 11935353]
<ref group="xtra">PMID:11935353</ref><references group="xtra"/>
[[Category: Equus caballus]]
[[Category: Equus caballus]]
[[Category: Single protein]]
[[Category: Andersson, K K.]]
[[Category: Andersson, K K.]]
[[Category: Gorbitz, C H.]]
[[Category: Gorbitz, C H.]]
Line 39: Line 36:
[[Category: Transport]]
[[Category: Transport]]
[[Category: X-ray-induced-photoreduction]]
[[Category: X-ray-induced-photoreduction]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:00:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:47:12 2009''

Revision as of 15:47, 16 February 2009

File:2vlz.png

Template:STRUCTURE 2vlz

CRYSTAL STRUCTURE OF PEROXYMYOGLOBIN GENERATED BY CRYORADIOLYTIC REDUCTION OF MYOGLOBIN COMPOUND III

About this Structure

2VLZ is a 1 chain structure of sequence from Equus caballus. Full crystallographic information is available from OCA.

Reference

  1. Hersleth HP, Dalhus B, Gorbitz CH, Andersson KK. An iron hydroxide moiety in the 1.35 A resolution structure of hydrogen peroxide derived myoglobin compound II at pH 5.2. J Biol Inorg Chem. 2002 Mar;7(3):299-304. Epub 2001 Oct 11. PMID:11935353 doi:10.1007/s007750100296

Page seeded by OCA on Mon Feb 16 17:47:12 2009

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2vlz&oldid=845290"