2ygs: Difference between revisions

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[[Image:2ygs.gif|left|200px]]
{{Seed}}
[[Image:2ygs.png|left|200px]]


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{{STRUCTURE_2ygs|  PDB=2ygs  |  SCENE=  }}  
{{STRUCTURE_2ygs|  PDB=2ygs  |  SCENE=  }}  


'''CARD DOMAIN FROM APAF-1'''
===CARD DOMAIN FROM APAF-1===




==Overview==
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Caspase-9-mediated apoptosis (programmed cell death) plays a central role in the development and homeostasis of all multicellular organisms. Mature caspase-9 is derived from its procaspase precursor as a result of recruitment by the activating factor Apaf-1. The crystal structures of the caspase-recruitment domain of Apaf-1 by itself and in complex with the prodomain of procaspase-9 have been determined at 1.6 and 2.5 A resolution, respectively. These structures and other evidence reveal that each molecule of Apaf-1 interacts with a molecule of procaspase-9 through two highly charged and complementary surfaces formed by non-conserved residues; these surfaces determine recognition specificity through networks of intermolecular hydrogen bonds and van der Waals interactions. Mutation of the important interface residues in procaspase-9 or Apaf-1 prevents or reduces activation of procaspase-9 in a cell-free system. Wild-type, but not mutant, prodomains of caspase-9 completely inhibit catalytic processing of procaspase-9. Furthermore, analysis of homologues from Caenorhabditis elegans indicates that recruitment of CED-3 by CED-4 is probably mediated by the same set of conserved structural motifs, with a corresponding change in the specificity-determining residues.
The line below this paragraph, {{ABSTRACT_PUBMED_10376594}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10376594}}


==About this Structure==
==About this Structure==
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[[Category: Caspase recruitment domain]]
[[Category: Caspase recruitment domain]]
[[Category: Recognition]]
[[Category: Recognition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:11:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:36:28 2008''

Revision as of 08:36, 29 July 2008

File:2ygs.png

Template:STRUCTURE 2ygs

CARD DOMAIN FROM APAF-1

Template:ABSTRACT PUBMED 10376594

About this Structure

2YGS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1., Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y, Nature. 1999 Jun 10;399(6736):549-57. PMID:10376594

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