2yxf: Difference between revisions

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[[Image:2yxf.gif|left|200px]]
{{Seed}}
[[Image:2yxf.png|left|200px]]


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{{STRUCTURE_2yxf|  PDB=2yxf  |  SCENE=  }}  
{{STRUCTURE_2yxf|  PDB=2yxf  |  SCENE=  }}  


'''The high resolution crystal structure of beta2-microglobulin under physiological conditions'''
===The high resolution crystal structure of beta2-microglobulin under physiological conditions===




==Overview==
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beta(2)-Microglobulin (beta2-m), a light chain of the major histocompatibility complex class I, forms amyloid fibrils in patients undergoing long-term haemodialysis, causing dialysis-related amyloidosis. Based on a comparison of the X-ray structure obtained at pH 5.7 and that of beta2-m in the histocompatibility complex, it has been proposed that the continuous D-strand observed in the crystal structure at pH 5.7 increases the propensity of beta2-m to self-associate via edge-to-edge interactions, thus initiating the formation of fibrils. To obtain further insight into the mechanism by which amyloid fibrils form, we determined the crystal structure of beta2-m at pH 7.0 at a resolution of up to 1.13 A. The crystal structure at pH 7.0 was basically the same as that at pH 5.6, suggesting that the conversion of the beta-bulge in strand D into a contiguous beta-strand is not unique to the crystals formed under slightly acidic conditions. In other words, although the formation of beta2-m fibrils was enhanced under acidic conditions, it remains unknown if it is related to the increased propensity for the disappearance of the beta-bulge in strand D. We consider that the enhanced fibrillation is more directly coupled with the decreased stability leading to the increased propensity of exposing amyloidogenic regions.
The line below this paragraph, {{ABSTRACT_PUBMED_17646174}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17646174}}


==Disease==
==Disease==
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[[Category: Nakagawa, A.]]
[[Category: Nakagawa, A.]]
[[Category: Immune system]]
[[Category: Immune system]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:38:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 01:33:29 2008''

Revision as of 22:33, 27 July 2008

File:2yxf.png

Template:STRUCTURE 2yxf

The high resolution crystal structure of beta2-microglobulin under physiological conditions

Template:ABSTRACT PUBMED 17646174

Disease

Known disease associated with this structure: Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

2YXF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution crystal structure of beta2-microglobulin formed at pH 7.0., Iwata K, Matsuura T, Sakurai K, Nakagawa A, Goto Y, J Biochem. 2007 Sep;142(3):413-9. Epub 2007 Jul 23. PMID:17646174

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