2z6p: Difference between revisions

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[[Image:2z6p.gif|left|200px]]
{{Seed}}
[[Image:2z6p.png|left|200px]]


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{{STRUCTURE_2z6p|  PDB=2z6p  |  SCENE=  }}  
{{STRUCTURE_2z6p|  PDB=2z6p  |  SCENE=  }}  


'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''
===Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1===




==Overview==
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Ubiquitin and ubiquitin-like protein-conjugating enzymes play central roles in posttranslational modification processes. The ubiquitin-fold modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is covalently attached to target proteins via Uba5 and Ufm1-conjugating enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the Ufm1 system likely plays important roles in various multicellular organisms. Herein, we report the X-ray structure of human Ufc1 determined at 1.6 A resolution. The Ufc1 structure comprises a canonical E2 domain and an additional N-terminal domain. The Uba5 binding site on Ufc1 was assigned by structural comparison of Ufc1 and Ubc12 and related mutational analyses. In addition, we show that the N-terminal unique domain of Ufc1 contributes to thermal stability.
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{{ABSTRACT_PUBMED_17825256}}


==About this Structure==
==About this Structure==
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[[Category: Ufc1]]
[[Category: Ufc1]]
[[Category: Ufm1]]
[[Category: Ufm1]]
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Revision as of 14:33, 27 July 2008

File:2z6p.png

Template:STRUCTURE 2z6p

Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1

Template:ABSTRACT PUBMED 17825256

About this Structure

2Z6P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256

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