2z94: Difference between revisions

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[[Image:2z94.jpg|left|200px]]
{{Seed}}
[[Image:2z94.png|left|200px]]


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{{STRUCTURE_2z94|  PDB=2z94  |  SCENE=  }}  
{{STRUCTURE_2z94|  PDB=2z94  |  SCENE=  }}  


'''Complex structure of SARS-CoV 3C-like protease with TDT'''
===Complex structure of SARS-CoV 3C-like protease with TDT===




==Overview==
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Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
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{{ABSTRACT_PUBMED_17981158}}


==About this Structure==
==About this Structure==
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[[Category: Complex]]
[[Category: Complex]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:03:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:09:16 2008''

Revision as of 05:09, 29 July 2008

File:2z94.png

Template:STRUCTURE 2z94

Complex structure of SARS-CoV 3C-like protease with TDT

Template:ABSTRACT PUBMED 17981158

About this Structure

2Z94 is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158

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