2z9q: Difference between revisions

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[[Image:2z9q.gif|left|200px]]
{{Seed}}
[[Image:2z9q.png|left|200px]]


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{{STRUCTURE_2z9q|  PDB=2z9q  |  SCENE=  }}  
{{STRUCTURE_2z9q|  PDB=2z9q  |  SCENE=  }}  


'''Transfer RNA in the hybrid P/E state'''
===Transfer RNA in the hybrid P/E state===


==Overview==
During the ribosomal translocation, the binding of elongation factor G (EF-G) to the pretranslocational ribosome leads to a ratchet-like rotation of the 30S subunit relative to the 50S subunit in the direction of the mRNA movement. By means of cryo-electron microscopy we observe that this rotation is accompanied by a 20 A movement of the L1 stalk of the 50S subunit, implying that this region is involved in the translocation of deacylated tRNAs from the P to the E site. These ribosomal motions can occur only when the P-site tRNA is deacylated. Prior to peptidyl-transfer to the A-site tRNA or peptide removal, the presence of the charged P-site tRNA locks the ribosome and prohibits both of these motions.


==About this Structure==
==About this Structure==
2Z9Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9Q OCA].  
2Z9Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9Q OCA].  


==Reference==
==Reference==
Locking and unlocking of ribosomal motions., Valle M, Zavialov A, Sengupta J, Rawat U, Ehrenberg M, Frank J, Cell. 2003 Jul 11;114(1):123-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12859903 12859903]
<ref group="xtra">PMID:12859903</ref><references group="xtra"/>
[[Category: Single protein]]
[[Category: Thermus aquaticus]]
[[Category: Thermus aquaticus]]
[[Category: Frank, J.]]
[[Category: Frank, J.]]
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Twisted cca arm]]
[[Category: Twisted cca arm]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:04:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 15 09:26:10 2009''

Revision as of 06:26, 15 April 2009

File:2z9q.png

Template:STRUCTURE 2z9q

Transfer RNA in the hybrid P/E state

About this Structure

2Z9Q is a 1 chain structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

  1. Valle M, Zavialov A, Sengupta J, Rawat U, Ehrenberg M, Frank J. Locking and unlocking of ribosomal motions. Cell. 2003 Jul 11;114(1):123-34. PMID:12859903

Page seeded by OCA on Wed Apr 15 09:26:10 2009

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