311d: Difference between revisions

Line 1:

[[Image:311d.~~gif~~|left|200px]]

[[Image:311d.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2~~'''~~

===THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2===

~~==Overview==~~

<!--

The ~~crystal structure is reported of a complex between the dodecanucleotide sequence d(CGCGAATTCGCG)2and an analogue of the DNA binding drug Hoechst 33258~~, ~~in which~~ the ~~piperazine ring has been replaced by an amidinium group and~~ the ~~phenol ring by a phenylamidinium group. The structure has been refined to an R factor of 19.5%~~ at 2.~~2 A resolution~~. ~~The drug is held in the minor groove by five strong hydrogen bonds, together with bridging water molecules at both ends. There are few other contacts with the floor of the groove~~, ~~indicating a lack of isohelicity with the groove and suggesting (i) that the observed high DNA affinity of this drug~~ is ~~primarily due to~~ the ~~array of hydrogen bonds and (ii) that these more than compensate for its poor isohelicity~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9162901}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9162901 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Complexed with drug]]

[[Category: Double helix]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:15:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:36:18 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:311d.gif|left|200px]]
+{{Seed}}
+[[Image:311d.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_311d|  PDB=311d  |  SCENE=  }}
-'''THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2'''
+===THE ROLE OF HYDROGEN BONDING IN MINOR-GROOVE DRUG-DNA RECOGNITION. STRUCTURE OF A BIS-AMIDINIUM DERIVATIVE OF HOECHST 33258 COMPLEXED TO THE DODECANUCLEOTIDE D(CGCGAATTCGCG)2===
-==Overview==
+<!--
-The crystal structure is reported of a complex between the dodecanucleotide sequence d(CGCGAATTCGCG)2and an analogue of the DNA binding drug Hoechst 33258, in which the piperazine ring has been replaced by an amidinium group and the phenol ring by a phenylamidinium group. The structure has been refined to an R factor of 19.5% at 2.2 A resolution. The drug is held in the minor groove by five strong hydrogen bonds, together with bridging water molecules at both ends. There are few other contacts with the floor of the groove, indicating a lack of isohelicity with the groove and suggesting (i) that the observed high DNA affinity of this drug is primarily due to the array of hydrogen bonds and (ii) that these more than compensate for its poor isohelicity.
+The line below this paragraph, {{ABSTRACT_PUBMED_9162901}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9162901 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9162901}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Complexed with drug]]
 [[Category: Double helix]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:15:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:36:18 2008''