357d: Difference between revisions

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[[Image:357d.gif|left|200px]]
{{Seed}}
[[Image:357d.png|left|200px]]


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{{STRUCTURE_357d|  PDB=357d  |  SCENE=  }}  
{{STRUCTURE_357d|  PDB=357d  |  SCENE=  }}  


'''3.5 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA'''
===3.5 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA===




==Overview==
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Two new RNA structures portray how non-Watson-Crick base pairs and metal ions can produce a unique RNA shape suitable for recognition by proteins. The crystal structures of a 62 nt domain of E. coli 5S ribosomal RNA and a duplex dodecamer encompassing an internal loop E have been determined at 3.0 and 1.5 A, respectively. This loop E region is distorted by three "cross-strand purine stacks" and three novel, water-mediated noncanonical base pairs and stabilized by a four metal ion zipper. These features give its minor groove a unique hydrogen-bonding surface and make the adjacent major groove wide enough to permit recognition by the ribosomal protein L25, which is expected to bind to this surface.
The line below this paragraph, {{ABSTRACT_PUBMED_9393863}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9393863}}


==About this Structure==
==About this Structure==
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[[Category: Overhanging base]]
[[Category: Overhanging base]]
[[Category: U-rna]]
[[Category: U-rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:17:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:30:35 2008''
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