365d: Difference between revisions

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[[Image:365d.~~gif~~|left|200px]]

[[Image:365d.png|left|200px]]

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~~'''~~STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE~~'''~~

===STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE===

~~==Overview==~~

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~~Small molecules that target specific DNA sequences offer a potentially general approach for~~ the ~~regulation of gene expression. Pyrrole-imidazole polyamides represent~~ the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (~~Im) and pyrrole (Py), distinguish G~~.~~C from C~~.G, ~~and both from A~~.~~T/T.A base pairs. A high resolution X~~-~~ray crystal structure of a four~~-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.

The line below this paragraph, {{ABSTRACT_PUBMED_9461074}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9461074 is the PubMed ID number.

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==About this Structure==

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[[Category: Double helix]]

[[Category: Modified]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 20~~:17:29 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:25:23 2008''

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-[[Image:365d.gif|left|200px]]
+{{Seed}}
+[[Image:365d.png|left|200px]]
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 {{STRUCTURE_365d|  PDB=365d  |  SCENE=  }}
-'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''
+===STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE===
-==Overview==
+<!--
-Small molecules that target specific DNA sequences offer a potentially general approach for the regulation of gene expression. Pyrrole-imidazole polyamides represent the only class of synthetic small molecules that can bind predetermined DNA sequences with affinities and specificities comparable to DNA binding proteins. Antiparallel side-by-side pairings of two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C from C.G, and both from A.T/T.A base pairs. A high resolution X-ray crystal structure of a four-ring pyrrole-imidazole polyamide specifically bound as a dimer to a six-base pair predetermined DNA site reveals a structural framework of hydrogen bonds and interactions with the walls of the minor groove that underlies the pairing rules for DNA recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_9461074}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9461074 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9461074}}
 ==About this Structure==
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 [[Category: Double helix]]
 [[Category: Modified]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:17:29 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:25:23 2008''