1aj4: Difference between revisions
New page: left|200px<br /><applet load="1aj4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1aj4" /> '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPO... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1aj4.gif|left|200px]]<br /><applet load="1aj4" size=" | [[Image:1aj4.gif|left|200px]]<br /><applet load="1aj4" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1aj4" /> | caption="1aj4" /> | ||
'''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE'''<br /> | '''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE'''<br /> | ||
==Overview== | ==Overview== | ||
The regulation of cardiac muscle contraction must differ from that of | The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction. | ||
==About this Structure== | ==About this Structure== | ||
1AJ4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1AJ4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJ4 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Gagne, S | [[Category: Gagne, S M.]] | ||
[[Category: Li, M | [[Category: Li, M X.]] | ||
[[Category: Liu, W.]] | [[Category: Liu, W.]] | ||
[[Category: Putkey, J | [[Category: Putkey, J A.]] | ||
[[Category: Sia, S | [[Category: Sia, S K.]] | ||
[[Category: Spyracopoulos, L.]] | [[Category: Spyracopoulos, L.]] | ||
[[Category: Sykes, B | [[Category: Sykes, B D.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: calcium binding]] | [[Category: calcium binding]] | ||
| Line 26: | Line 26: | ||
[[Category: regulatory]] | [[Category: regulatory]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:45:05 2008'' | ||
Revision as of 09:45, 21 February 2008
|
STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 1 STRUCTURE
Overview
The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.
About this Structure
1AJ4 is a Single protein structure of sequence from Gallus gallus with CA as ligand. Full crystallographic information is available from OCA.
Reference
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:9218458
Page seeded by OCA on Thu Feb 21 11:45:05 2008
