3b2w: Difference between revisions

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[[Image:3b2w.jpg|left|200px]]
{{Seed}}
[[Image:3b2w.png|left|200px]]


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{{STRUCTURE_3b2w|  PDB=3b2w  |  SCENE=  }}  
{{STRUCTURE_3b2w|  PDB=3b2w  |  SCENE=  }}  


'''Crystal structure of pyrimidine amide 11 bound to Lck'''
===Crystal structure of pyrimidine amide 11 bound to Lck===




==Overview==
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N-3-(Phenylcarbamoyl)arylpyrimidine-5-carboxamides are a novel class of selective Lck inhibitors. This series of compounds derives its selectivity from a hydrogen bond with the gatekeeper Thr316 of the enzyme. X-ray co-crystal structural data, structure-activity relationships, and the synthesis of these inhibitors are reported herein.
The line below this paragraph, {{ABSTRACT_PUBMED_18083554}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18083554}}


==Disease==
==Disease==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:20:25 2008''
 
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