3b3q: Difference between revisions

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[[Image:3b3q.jpg|left|200px]]
{{Seed}}
[[Image:3b3q.png|left|200px]]


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{{STRUCTURE_3b3q|  PDB=3b3q  |  SCENE=  }}  
{{STRUCTURE_3b3q|  PDB=3b3q  |  SCENE=  }}  


'''Crystal structure of a synaptic adhesion complex'''
===Crystal structure of a synaptic adhesion complex===




==Overview==
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The heterophilic synaptic adhesion molecules neuroligins and neurexins are essential for establishing and maintaining neuronal circuits by modulating the formation and maturation of synapses. The neuroligin-neurexin adhesion is Ca2+-dependent and regulated by alternative splicing. We report a structure of the complex at a resolution of 2.4 A between the mouse neuroligin-1 (NL1) cholinesterase-like domain and the mouse neurexin-1beta (NX1beta) LNS (laminin, neurexin and sex hormone-binding globulin-like) domain. The structure revealed a delicate neuroligin-neurexin assembly mediated by a hydrophilic, Ca2+-mediated and solvent-supplemented interface, rendering it capable of being modulated by alternative splicing and other regulatory factors. Thermodynamic data supported a mechanism wherein splicing site B of NL1 acts by modulating a salt bridge at the edge of the NL1-NX1beta interface. Mapping neuroligin mutations implicated in autism indicated that most such mutations are structurally destabilizing, supporting deficient neuroligin biosynthesis and processing as a common cause for this brain disorder.
The line below this paragraph, {{ABSTRACT_PUBMED_18084303}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18084303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084303}}
 
==Disease==
Known disease associated with this structure: Autism, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600565 600565]]


==About this Structure==
==About this Structure==
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[[Category: Synaptic formation]]
[[Category: Synaptic formation]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:21:40 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:40:26 2008''

Revision as of 03:40, 28 July 2008

File:3b3q.png

Template:STRUCTURE 3b3q

Crystal structure of a synaptic adhesion complex

Template:ABSTRACT PUBMED 18084303

Disease

Known disease associated with this structure: Autism, susceptibility to OMIM:[600565]

About this Structure

3B3Q is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions., Chen X, Liu H, Shim AH, Focia PJ, He X, Nat Struct Mol Biol. 2008 Jan;15(1):50-6. Epub 2007 Dec 16. PMID:18084303

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