3bes: Difference between revisions

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{{STRUCTURE_3bes|  PDB=3bes  |  SCENE=  }}  
{{STRUCTURE_3bes|  PDB=3bes  |  SCENE=  }}  


'''Structure of a Poxvirus ifngbp/ifng Complex'''
===Structure of a Poxvirus ifngbp/ifng Complex===




==Overview==
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Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important virulence factor that is highly conserved (&gt;90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a 57-aa helix-turn-helix (HTH) motif that is structurally related to the transcription factor TFIIA. The HTH motif forms a tetramerization domain that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined with biochemical and cell-based assays, demonstrates that IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma antagonism.
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==Disease==
==Disease==
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[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Receptor]]
[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:41:16 2008''

Revision as of 10:41, 27 July 2008

File:3bes.png

Template:STRUCTURE 3bes

Structure of a Poxvirus ifngbp/ifng Complex

Template:ABSTRACT PUBMED 18252829

Disease

Known disease associated with this structure: AIDS, rapid progression to OMIM:[147570], Aplastic anemia OMIM:[147570], Interferon, immune, deficiency OMIM:[147570], Hepatitis C virus, resistance to OMIM:[147570], TSC2 angiomyolipomas, renal, modifier of OMIM:[147570], Tuberculosis, susceptibility to OMIM:[147570]

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-gamma antagonism by an orthopoxvirus IFN-gamma-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1861-6. Epub 2008 Feb 5. PMID:18252829

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