3bfg: Difference between revisions

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[[Image:3bfg.jpg|left|200px]]
{{Seed}}
[[Image:3bfg.png|left|200px]]


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{{STRUCTURE_3bfg|  PDB=3bfg  |  SCENE=  }}  
{{STRUCTURE_3bfg|  PDB=3bfg  |  SCENE=  }}  


'''class A beta-lactamase SED-G238C complexed with meropenem'''
===class A beta-lactamase SED-G238C complexed with meropenem===


==Overview==
SED-1, a class A beta-lactamase from Citrobacter sedlakii, is a CTX-M-type extended-spectrum beta-lactamase that has the ability to hydrolyze expanded-spectrum cephalosporins such as cefotaxime. SED-1 and a SED mutant in which Gly238 has been replaced by a cysteine, forming a disulfide bridge with the other Cys residue located at position 69 (SED-G238C), have been crystallized. The crystals belong to the monoclinic space group C2, with unit-cell parameters a = 188.09, b = 73.65, c = 105.41 A, beta = 121.67 degrees for SED-1 and a = 187.64, b = 73.2, c = 103.89 A, beta = 121.89 degrees for the SED-G238C mutant. X-ray diffraction data were collected to maximum resolutions of 2.4 A for SED-1 and 2.0 A for SED-G238C.


==About this Structure==
==About this Structure==
3BFG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Citrobacter_sedlakii Citrobacter sedlakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFG OCA].  
3BFG is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Citrobacter_sedlakii Citrobacter sedlakii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BFG OCA].  


==Reference==
==Reference==
Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii., Petrella S, Pernot L, Sougakoff W, Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):125-8. Epub 2003, Dec 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14684905 14684905]
<ref group="xtra">PMID:14684905</ref><references group="xtra"/>
[[Category: Beta-lactamase]]
[[Category: Beta-lactamase]]
[[Category: Citrobacter sedlakii]]
[[Category: Citrobacter sedlakii]]
[[Category: Single protein]]
[[Category: Pernot, L.]]
[[Category: Pernot, L.]]
[[Category: Petrella, S.]]
[[Category: Petrella, S.]]
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[[Category: Meropenem]]
[[Category: Meropenem]]
[[Category: Sed-g238c]]
[[Category: Sed-g238c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 15:07:11 2009''

Revision as of 13:07, 17 February 2009

File:3bfg.png

Template:STRUCTURE 3bfg

class A beta-lactamase SED-G238C complexed with meropenem

About this Structure

3BFG is a 4 chains structure of sequences from Citrobacter sedlakii. Full crystallographic information is available from OCA.

Reference

  1. Petrella S, Pernot L, Sougakoff W. Crystallization and preliminary X-ray diffraction study of the class A beta-lactamase SED-1 and its mutant SED-G238C from Citrobacter sedlakii. Acta Crystallogr D Biol Crystallogr. 2004 Jan;60(Pt 1):125-8. Epub 2003, Dec 18. PMID:14684905

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