3bgs: Difference between revisions

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[[Image:3bgs.jpg|left|200px]]
{{Seed}}
[[Image:3bgs.png|left|200px]]


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{{STRUCTURE_3bgs|  PDB=3bgs  |  SCENE=  }}  
{{STRUCTURE_3bgs|  PDB=3bgs  |  SCENE=  }}  


'''Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate'''
===Structure of human purine nucleoside phosphorylase with L-DADMe-ImmH and phosphate===




==Overview==
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Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.
The line below this paragraph, {{ABSTRACT_PUBMED_18154341}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18154341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18154341}}


==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Transition state analogue]]
[[Category: Transition state analogue]]
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