3bl0: Difference between revisions

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[[Image:3bl0.jpg|left|200px]]
{{Seed}}
[[Image:3bl0.png|left|200px]]


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{{STRUCTURE_3bl0|  PDB=3bl0  |  SCENE=  }}  
{{STRUCTURE_3bl0|  PDB=3bl0  |  SCENE=  }}  


'''Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies'''
===Carbonic anhydrase inhibitors. Interaction of 2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies===




==Overview==
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2-N,N-Dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide was tested for its interaction with the 12 catalytically active mammalian carbonic anhydrase (CA, EC 4.2.1.1) isozymes, CA I-XIV. The compound is a potent inhibitor of CA IV, VII, IX, XII, and XIII (K(I)s of 0.61-39 nM), a medium potency inhibitor of CA II and VA (K(I)s of 121-438 nM), and a weak inhibitor against the other isoforms (CA III, VB, VI, and XIV), making it a very interesting candidate for situations in which a strong/selective inhibition of certain isozymes is needed. The crystal structure of the hCA II adduct of this sulfonamide revealed interesting interactions between the inhibitor and the enzyme which are quite different from those observed in the adducts of CA II with the structurally related aliphatic derivatives zonisamide, 2-amino-1,3,4-thiadiazolyl-5-difluoromethanesulfonamide, and 2-dimethylamino-5-[sulfonamido-(aminomethyl)]-1,3,4-thiadiazole reported earlier.
The line below this paragraph, {{ABSTRACT_PUBMED_18162396}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18162396}}


==About this Structure==
==About this Structure==
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[[Category: Sulfonamide]]
[[Category: Sulfonamide]]
[[Category: Zinc]]
[[Category: Zinc]]
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