1apc: Difference between revisions

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[[Image:1apc.gif|left|200px]]<br /><applet load="1apc" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1apc.gif|left|200px]]<br /><applet load="1apc" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1apc" />

'''SOLUTION STRUCTURE OF APOCYTOCHROME B562'''<br />

==Overview==

The apoprotein is an important intermediate on the folding pathways of, many haem proteins, yet a detailed structure of such an intermediate has, remained elusive. Here we present the structure of apocytochrome b562, obtained by NMR spectroscopy. The apoprotein has a topology similar to the, holoprotein. Nevertheless, significant differences in helix-helix packing, between the two are evident. Much of the haem binding pocket in the, apoprotein is preserved but exposed to solvent creating a large cavern. As, apocytochrome b562 displays many of the physical characteristics ascribed, to the molten globule state, these results help ellucidate the origin of, several properties of the protein molten globule.

The apoprotein is an important intermediate on the folding pathways of many haem proteins, yet a detailed structure of such an intermediate has remained elusive. Here we present the structure of apocytochrome b562 obtained by NMR spectroscopy. The apoprotein has a topology similar to the holoprotein. Nevertheless, significant differences in helix-helix packing between the two are evident. Much of the haem binding pocket in the apoprotein is preserved but exposed to solvent creating a large cavern. As apocytochrome b562 displays many of the physical characteristics ascribed to the molten globule state, these results help ellucidate the origin of several properties of the protein molten globule.

==About this Structure==

1APC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA].

1APC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA].

==Reference==

Line 14:

[[Category: Single protein]]

[[Category: Feng, Y.]]

[[Category: Sligar, S.G.]]

[[Category: Sligar, S G.]]

[[Category: Wand, A.J.]]

[[Category: Wand, A J.]]

[[Category: electron transport]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:57 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1apc.gif|left|200px]]<br /><applet load="1apc" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1apc.gif|left|200px]]<br /><applet load="1apc" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1apc" />
 '''SOLUTION STRUCTURE OF APOCYTOCHROME B562'''<br />
 ==Overview==
-The apoprotein is an important intermediate on the folding pathways of, many haem proteins, yet a detailed structure of such an intermediate has, remained elusive. Here we present the structure of apocytochrome b562, obtained by NMR spectroscopy. The apoprotein has a topology similar to the, holoprotein. Nevertheless, significant differences in helix-helix packing, between the two are evident. Much of the haem binding pocket in the, apoprotein is preserved but exposed to solvent creating a large cavern. As, apocytochrome b562 displays many of the physical characteristics ascribed, to the molten globule state, these results help ellucidate the origin of, several properties of the protein molten globule.
+The apoprotein is an important intermediate on the folding pathways of many haem proteins, yet a detailed structure of such an intermediate has remained elusive. Here we present the structure of apocytochrome b562 obtained by NMR spectroscopy. The apoprotein has a topology similar to the holoprotein. Nevertheless, significant differences in helix-helix packing between the two are evident. Much of the haem binding pocket in the apoprotein is preserved but exposed to solvent creating a large cavern. As apocytochrome b562 displays many of the physical characteristics ascribed to the molten globule state, these results help ellucidate the origin of several properties of the protein molten globule.
 ==About this Structure==
-APC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA].
+APC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1APC OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Feng, Y.]]
-[[Category: Sligar, S.G.]]
+[[Category: Sligar, S G.]]
-[[Category: Wand, A.J.]]
+[[Category: Wand, A J.]]
 [[Category: electron transport]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:01:20 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:57 2008''