3btv: Difference between revisions

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[[Image:3btv.jpg|left|200px]]
{{Seed}}
[[Image:3btv.png|left|200px]]


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{{STRUCTURE_3btv|  PDB=3btv  |  SCENE=  }}  
{{STRUCTURE_3btv|  PDB=3btv  |  SCENE=  }}  


'''Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S0)-[G301R]'''
===Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S0)-[G301R]===




==Overview==
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Transcriptional regulation of the galactose-metabolizing genes in Saccharomyces cerevisiae depends on three core proteins: Gal4p, the transcriptional activator that binds to upstream activating DNA sequences (UAS(GAL)); Gal80p, a repressor that binds to the carboxyl terminus of Gal4p and inhibits transcription; and Gal3p, a cytoplasmic transducer that, upon binding galactose and adenosine 5'-triphosphate, relieves Gal80p repression. The current model of induction relies on Gal3p sequestering Gal80p in the cytoplasm. However, the rapid induction of this system implies that there is a missing factor. Our structure of Gal80p in complex with a peptide from the carboxyl-terminal activation domain of Gal4p reveals the existence of a dinucleotide that mediates the interaction between the two. Biochemical and in vivo experiments suggests that nicotinamide adenine dinucleotide phosphate (NADP) plays a key role in the initial induction event.
The line below this paragraph, {{ABSTRACT_PUBMED_18292341}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 18292341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18292341}}


==About this Structure==
==About this Structure==
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[[Category: Galactose metabolism]]
[[Category: Galactose metabolism]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:05:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:50:52 2008''
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