3caa: Difference between revisions

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[[Image:3caa.gif|left|200px]]
{{Seed}}
[[Image:3caa.png|left|200px]]


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{{STRUCTURE_3caa|  PDB=3caa  |  SCENE=  }}  
{{STRUCTURE_3caa|  PDB=3caa  |  SCENE=  }}  


'''CLEAVED ANTICHYMOTRYPSIN A347R'''
===CLEAVED ANTICHYMOTRYPSIN A347R===




==Overview==
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A hallmark of serpin function is the massive beta-sheet rearrangement involving the insertion of the cleaved reactive loop into beta-sheet A as strand s4A. This structural transition is required for inhibitory activity. Small hydrophobic residues at P14 and P12 positions of the reactive loop facilitate this transition, since these residues must pack in the hydrophobic core of the cleaved serpin. Despite the radical substitution of arginine at the P12 position, the crystal structure of cleaved A347R antichymotrypsin reveals full strand s4A insertion with normal beta-sheet A geometry; the R347 side chain is buried in the hydrophobic protein core. In contrast, the structure of cleaved P14 T345R antichymotrypsin reveals substantial yet incomplete strand s4A insertion, without burial of the R345 side chain.
The line below this paragraph, {{ABSTRACT_PUBMED_8836107}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8836107 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8836107}}


==Disease==
==Disease==
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[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
[[Category: Serpin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 21:30:47 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:37:48 2008''
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